Analysis of the Platynereis dumerilii connectome with CATMAID and R

Gáspár Jékely
Centre for Organismal Studies, Heidelberg University

How do brains work?

“As simple as possible - but complete”

Zooplankton behaviour

phototaxis

startle response

The simplest circuit to mediate behaviour - phototaxis

Platynereis - a marine annelid

Whole-body connectome of a segmented annelid larva

Information flow from sensors to effectors

Whole-body coordination of cilia

Whole-body coordination of cilia

Whole-body coordination during startle

Coordinated arrest of all cilia

No arrest in polycystin receptor mutant

Startle recruits body-wide circuits and effectors

Pressure response in Platynereis larvae

Pressure response is graded

Pressure is sensed by photoreceptors with ramified cilia

cPRC - ciliated Photoreceptor Cells

UV response in Platynereis larvae

Circuitry of ciliary photoreceptors

Part 1 - The online CATMAID interface

CATMAID = Collaborative Annotation Toolkit for Massive Amounts of Image Data

Navigate to:

https://catmaid.jekelylab.ex.ac.uk/

Platynereis CATMAID server